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Due to impaired health William's physician advised a career move to China.[1] In 1833, he traveled to Canton, China and took over a partnership in Dunn & Company. He formed close ties with a junior partner Joseph Archer.[2] He went on to establish a new merchant house, Wetmore & Company, with Joseph Archer. Wetmore's profit and loss ledgers from 1834–1839 reveal that the primary goods brokered by Wetmore & Co. were tea, tea papers, silks and spices. Lesser cargoes were wines, ports, opium, hemp, pearl buttons, copper and coffee. They also transported a variety of foreign currencies, and delivered Sunday newspapers. "Fast boats" were commonly employed for personal passages and letters.[1] The company went on to be one of the largest mercantile houses in the East Indies despite the fact that Wetmore was opposed to the opium trade.[5] During his time in the Far East, Wetmore collected a variety of Chinese objects, porcelains and china, which he imported home.[1]
It was in 1835 that the Maryland merchant George Peabody sailed to London on a mission to defer a United States banking crisis when states had begun skipping interest payments on bonds marketed in London. Peabody eventually enjoyed a huge success as a merchant banker in London and as a self-appointed American ambassador of the mercantile industry. He developed a form of wholesale banking known as merchant banks and became a leading dealer of American state bonds in London. It was through family and business connections that William S. Wetmore began a lifelong friendship with the prominent financier Peabody.[1]
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